Unified Approach to Highly Functionalized Clovane-type Terpenoids: Enantiocontrolled Total Synthesis of Rumphellclovane E, Sarinfacetamides A and B

Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC04197J, Edge Article Daigo Ninomiya, Shota Nagasawa, Yoshiharu Iwabuchi This study presents an enantioselective collective total synthesis of the highly functionalized clovane-type terpenoids rumphellclovane E (4), sarinfacetamides A (5), and B (6). An efficient enantio-controlled, second-generation route to an...