Unlocking the Potential of Risk-Based Screening for Breast Cancer

Breast cancer is the most frequently diagnosed malignant neoplasm among women in the US and remains a leading cause of cancer mortality. In 2025, an estimated 316 950 women were diagnosed with invasive disease and 42 170 died, reflecting a lifetime risk of approximately 1 in 8. These patterns in breast cancer morbidity and mortality underscore the continued need for advances in prevention, screening, and treatment.