A difluorocarbene-triggered annulation/ring expansion cascade via sequential single-atom-insertions: direct assembly of 2-fluoroquinazolinones from azo compounds

Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC00897F, Edge Article Yingxian Tian, Yiyan Xiong, Jingyu Wei, Gongming Zhu, Junbiao Chang, Bingxian Liu An efficient difluorocarbene-mediated tandem strategy for the synthesis of 2-fluoroquinazolin-4(3H)-ones via a sequential single-atom-insertion process has been developed.