Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC04438G, Edge Article Haiwen Wang, Nilanjan Bhaduri, Michael F. Greaney We report a skeletal rearrangement of pyridines that enables functionalisation of the 2 and 3-positions, via Zincke ketone intermediates.

Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC03791G, Edge Article Stephan K. Pedersen, Michael L. Steigerwald, Colin Nuckolls, Michael Pittelkow An electron deficient multi-helical penta-perylene with an amplified, broadband chiroptical response was prepared by the fusion of perylene and perylenediimide (PDI). This contorted nano-carbon contains 29 fused benzene rings.

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC02521H, Edge Article Kaixin Zhang, Zuo-Chang Chen, shuaipeng jia, Yang-Rong Yao, Hanrui Tian, Qing-Song Deng, Xue-Miao Wu, Jun Li, Shun-Liu Deng, Su-Yuan Xie, Qianyan Zhang Current OBO-doped nanographenes (NGs) are predominantly planar, and the precise synthesis of curved OBO-doped NGs remains a challenge owing to their limited thermodynamic stability. Herein, we report a two-step synthesis...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC02806C, Edge Article Yusuke Ishii, Chisato Hanafusa, Hajime Suzuki, Daichi Kato, Osamu Tomita, Akinobu Nakada, Shunsuke Nozawa, Akinori Saeki, Ryu Abe Interlayer-active layered oxysulfides, which exhibit both interlayer hydration and ion-exchange capabilities, have recently emerged as a new class of visible-light-driven photocatalysts for water splitting. However, the utilization of interlayer galleries...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03405E, Edge Article David Thomas Hogan, Alexander R. Krappe, R Feyerherm, Manuela Weber, Ute Resch-Genger, Siegfried Eigler Many commonly used dye classes suffer from strong overlap of their absorption and emission spectra, favoring reabsorption and hampering the combinaton of several dyes for multi-analyte sensing with single wavelength...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC02302A, Edge Article Hajime Suzuki, Akitoshi Nakamura, Miyuki Ikeda, Toshiki Abe, Yuuki Iida, Osamu Tomita, Masanobu Higashi, Shunsuke Nozawa, Akinori Saeki, Ryu Abe Continuous and compositionally controllable band-structure tuning remains a central challenge in visible-light-driven photocatalytic water splitting. Here, we demonstrate that layered bismuth oxyhalide solid solutions (BiOBr1-xIx) can provide a continuously tunable...

Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC02765B, Perspective Xiaoyu Wu, Jianwen Jiang Integrating synthetic likelihood with digital MOF discovery.

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC02948E, Edge Article Sebastian Knoll, Heiner Schmidt, Kevin Sowa, Benjamin Dietzek-Ivanšić, Celina Titze, Stephan Kupfer, Linda Zedler, Carsten Streb The design of covalently linked photoactive donor-acceptor dyads offers major opportunities for photocatalysis and solar energy conversion. Here, we report a noble metal-free dyad obtained by covalent anchoring of a...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC04008J, Edge Article Xuele Xu, Zihan Yan, Jiachen Ying, Linghao Deng, Mingxing Liu, Yifei Xu, Yao Liu, Yiwen Zhang, Yizhou Zhu, Yongyao Xia, Yonggang Wang The Zr-based halide solid-state electrolyte (SE) Li₂ZrCl₆ (LZC) has emerged as a promising candidate for all-solid-state lithium metal batteries (ASSLBs) due to the natural abundance and low cost of zirconium....

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC02478E, Review Article Jia-Lin Tu, Lin Guo, Binbin Huang, Wujiong Xia Undirected terminal C(sp3)–H functionalization represents a fundamental challenge in organic synthesis. Although early transition-metal-, enzyme-, and zeolite-based platforms have achieved high terminal selectivity through well-defined steric control mechanisms, a unifying...

Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC02382G, Edge Article Wu-Jie Guo, Shirong Yan, Shihao Xu, Tongfei Qi, Hui-Qing Peng This study presents a TICT-driven strategy for efficient OURTP in minimalist single-benzene luminophores, where TICT-induced ΔEST reduction and SOC amplification promote triplet population, enabling 12-fold τP and 9-fold ΦP enhancement.

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03487J, Edge Article Ryan T. Steele, Julius Domack, Richmond Sarpong Herein, we report a Stevens rearrangement ring expansion of isoindolines to N-alkyl-2-aroyl-tetrahydroisoquinolines, followed by a photochemical nitrogen atom extruding ring contraction and elimination to give indene derivatives. By combining the...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03972C, Edge Article Zhengyu Wei, Lingzhe Meng, Xue Qin, Wei Han, Xuelin Gong, Yiting Shi, Faheem Naseem, Wei Wei Organic electrodes suffer from poor active site accessibility, sluggish charge transport, and structural degradation upon cycling, limiting their practical application for energy storage. To address these challenges, this work elucidates...

Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC01375A, Edge Article Guang Yang, Minghao Yang, Zeshuo Meng, Yi Cui Single-atom cocatalysts play two roles in alkaline HER: regulating the electronic structure of adjacent active sites and modulating the proton environment. The synergistic interplay of these effects enhances alkaline HER performance.

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC02823C, Review Article Weimo Li, Xiwen Huang, Lin Xu, Xiaofeng Lu, Zhengquan Li The electronic structure of catalysts often undergoes irreversible transformation during electrocatalysis under applied potential, significantly impacting their activity and stability. Recent studies have revealed the critical role of the electron...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC02457B, Review Article Zhe Huang, Yixuan Zhao, Yonglin Wang, Yuning Li Lithium-sulfur batteries (LSBs) are considered as promising next-generation energy-storage systems because of their high theoretical energy density, low cost, material abundance, and environmental compatibility. Over the past decade, intensive research...

Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC90114J, Editorial We would like to take this opportunity to highlight the Outstanding Reviewers for Chemical Science in 2025, as selected by the editorial team for their significant contribution to the journal.

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03387C, Perspective Masamu Kawada, Seunghyun Sim Engineered living materials (ELMs) integrate living functionalities into synthetic materials. Although most ELM studies emphasize cellular functionality, the polymer matrix represents an equally powerful design space: not merely a passive...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03331H, Perspective Zhiyong Bai, Junhua Luo, Kang Min Ok Ultraviolet (UV) nonlinear optical (NLO) materials are essential for modern laser technologies; however, the development of new materials that simultaneously exhibit wide band gaps, large second-harmonic generation (SHG) responses, and...

Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC03833F, Edge Article Jonas Becker, Beatriz Dias-Barbieri, Robin J. Shattock, C. Remzi Becer Targeted and efficient delivery of nucleic acid therapeutics (NATs) is one of the major challenges in the development of next generation vaccine formulations.

Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC02040B, Comment Glenn Keith Kim Clothier, Simon Harrisson Reanalysis of flow polymerization kinetics of TBD-catalyzed L-lactide polymerization using an initial-rate approach reveals deviations from first-order behavior and supports a revised rate law.

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03024F, Edge Article Abhay Potluri, Justin B Siegel, Dean J Tantillo The mechanism of 1,8-cineole formation in Streptomyces clavuligerus 1,8-cineole synthase was reinvestigated using the TerDockin modeling approach and compared to that in Salvia fruticosa. The results of these simulations provided...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC02310J, Edge Article Hai-Jun Li, Biying Xi, Hui-Xian Jing, Xin Li, Hongnan Jia, Manman Fan, Weiguo Zhu, Rui Feng, Baorui Hao, Shi-Jun Li, Bing Yu, Yu Lan, Jingzhen Du The classic Büchner reaction involves the insertion of highly reactive carbenoids into benzene rings to form cycloheptatrienes. Achieving a Büchner-type ring expansion using stable terminal alkynes as carbon sources, however,...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC02074G, Edge Article Weiqing Wang, Yue Tang, Zhenqiang Zhang, Wenjun Wang, Junzheng Meng, Wenxiao Wu, Yuanzhu Jiang, Zhenzhen Chen, Weifeng Li, Yanmei Yang, Yuguo Chen, Bo Tang Exhaled breath (EB) harbors rich molecular information, providing important insights into multiple metabolism processes of the living body. Thus, EB analysis is believed to be a promising diagnostic method for...

Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC90124G, Correction Riliga Wu, Tongyue Wu, Weijiang Guan, Chao Lu

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03065C, Perspective Hao Liu, Yan Fu, Jacky Wing Yip Lam, Ben Zhong Tang, Zujin Zhao Organometallic phosphorescent materials have been developed as the critical luminescent materials for organic lightemitting diodes (OLEDs). However, most purely organic room-temperature phosphorescence (RTP) materials without any hevay metals are still...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC01862A, Edge Article Sumit Roy, Shreya Tyagi, Pramod P Pillai Autonomous reversibility is fundamental to many natural systems, enabling the formation of dynamic and adaptive assemblies without continuous external intervention. Replicating autonomous behavior in artificial systems remains challenging, as it...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03869G, Review Article Xia Chen, Chengming Huang, Jin Liu, Qiong Xiang, Ling Zhang, Xun Huang, Li Li, Zidong Wei Water electrolysis is widely acknowledged as a vital pathway for achieving deep decarbonization and facilitating large-scale integration of renewable energy sources. Nonetheless, the anodic oxygen evolution reaction (OER) presents a...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03006H, Edge Article Jake Sypniewski, Yong-Sok Lee, Phuc Tran, Sean Costner, Fabrice G Siméon, Victor W Pike [18F]Fluoroarenes feature prominently as radiotracers for biomedical imaging with positron emission tomography (PET). We report the syntheses of a wide range of triphenylselenonium triflates and demonstrate their reactivity towards cyclotron-produced...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03456J, Edge Article Dan Liu, Fang-Zhou Li, Yu-Ping He, Hua Wu The incorporation of phosphonate moieties into azaarenes via C-H functionalization is of paramount importance in pharmaceutical research, yet it remains a formidable synthetic challenge. Herein, we report an intermolecular cyclizative...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03026B, Edge Article Brandon Johnston, Meng-Fu Chen, Mingxuan Zhu, Peng Guo, Su-Yang Xu, Joonho Lee, Daniel G. Nocera Topological materials have been reported as active and selective electrochemical catalysts for a variety of small-molecule energy-conversion reactions. The exceptional activity and selectivity of these materials have been attributed to...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03152H, Edge Article Firoz Ahmed, Michael Isaac Jacobs The net charge on droplets is predicted to play a crucial role in accelerating chemical reactions in microdroplets by either altering reaction energetics or changing surface compositions. However, there are...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC01497F, Edge Article yuli zhuang, Xia Liu, Yuxuan Shen, Qiuyue Wang, Zhimin Lin, Qian Zeng, Xin Chen, Linye Jiang, Shao Yao, Jingyan Ge Mitochondria-targeted RNA therapeutics hold promise for treating mitochondrial disorders and cancer, yet effective mitochondrial gene modulation remains challenging due to the strong negative charge and intrinsic instability of RNA, which...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03192G, Perspective Matthew E. Lowe, Matthew N Hopkinson, Dominik Kubicki, Erli Lu, Roly J. Armstrong Polytetrafluoroethylene (PTFE) is a polymeric material that displays remarkable thermal and chemical stability. These properties have allowed for the widespread application of PTFE in both everyday and specialist environments but...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03277J, Edge Article Lingyi Kong, Zhe Chen, Yuheng Chen, Lingxiao Wang, Yu Wang, Yafei Li Electrolyte cations are widely recognized as critical promoters in electrochemical CO2 reduction reaction (CO2RR), yet the field has largely focused on cation identity while overlooking a more fundamental and practical...

Tetraphenylmethane motifs are valuable in molecular electronics and porous materials, but their central sp3 carbon hinders conductivity. This research introduces a new class of tetraphenylethanes that utilize a rigid, conjugated core. These molecules exhibit enhanced electronic communication and improved charge transport properties. This advancement opens new avenues for designing efficient molecular electronic devices.

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC01097K, Edge Article Chunchun Mi, Liangzhuo Ma, Xuan Wen, Yuqi Hou, Xuelin Dao, Aidong Peng, Qinqin Shi, Hui Huang Visible-light-absorbing, metal-free photoredox catalysts are attractive because they are inexpensive and offer tunable redox potentials. However, the use of organic photocatalysts is often limited by their incompatibility with strongly acidic...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC02492K, Edge Article Xue Lou, Wenkai Liu, Mingwang Yang, Hua Zhang, Jiangli Fan, Xiaojun Peng Antitumor agents that rely solely on apoptosis often fail to disrupt the complementary cell survival cascades. In this study, we developed a redox-responsive integrated therapeutic system (QSH) that exploited ferroptosis...

Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC02144A, Edge Article Tsubasa Mikie, Keitaro Iguchi, Ryosuke Kamimura, Kenta Tanaka, Hiroyuki Ishii, Itaru Osaka Quinoid-controlled suppression of bond-length alternation promotes π-electron delocalization and efficient intrachain charge transport, enabling charge mobility to exceed 4 cm2 V−1 s−1 in fully non-fused S-Pechmann-based π-conjugated polymers.

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D5SC09784C, Edge Article Peikun Zheng, Yuriy Abramov, Changquan Calvin Sun, Olexandr Isayev The crystal form a drug adopts can change everything from how it dissolves to whether it works in the clinic, yet predicting which polymorphs a flexible molecule will produce remains...

Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC90123A, Correction Puja Saha, Deepanjan Panda, Diana Müller, Arunabha Maity, Harald Schwalbe, Jyotirmayee Dash

Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC02112C, Review Article Thi Thu Huong Chu, Dan N. Le, Minjong Lee, Dushyant M. Narayan, Doo San Kim, Soham Shirodkar, Minki Choe, Suyoung Yoo, Nikhil Tiwale, Rino Choi, Jinho Ahn, Myung Mo Sung, Chang-Yong Nam, Jiyoung Kim This review highlights recent progress in vapour-phase strategies for EUV resists, emphasizing dry resist design and solvent-free development toward high-fidelity patterning for high- and hyper-NA lithography.

Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC02775J, Edge Article Xinliang Cai, Rajat Walia, Weixiong Guo, Yexuan Pu, Jinbei Wei, Xian-Kai Chen, Yue Wang A series of multi-resonance thermally activated delayed fluorescence (MR-TADF) isomers were synthesized and employed as model molecules to elucidate the fundamental structure–property relationships governing emission.

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC00974C, Edge Article Evan I Stern, Kira A Thurman, Fernanda Brito dos Santos, Paul Andrew Kempler During electrodeposition and corrosion reactions, dissolved metal ions transfer across the electrochemical double layer, undergoing changes in their solvation environment and oxidation state. The solvent reorganization during charge transfer is...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03246J, Edge Article Chenlan Li, Linda Yang, Yang Li, Jian-Quan Liu, Yihan Chen Natural chiral dopants have been widely employed in liquid crystal displays, biomedicine, and chiral optical materials owing to their easy availability of chirality and excellent biocompatibility. However, most natural chiral...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03645G, Edge Article Claire Miesch, Ewelina Krolicka, Robert Mayer, David Leboeuf A divergent synthetic strategy to access γ-arylated ketones and α-arylated tetrahydrofurans from readily available homopropargylic alcohols and arene nucleophiles is reported. This method expands the accessible chemical space of γ-arylated...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC00941G, Edge Article Md Ashif Ali, Ji Heon Kim, Younghun Kim, Yunwoo Nam, Juwon Oh, Woo-Dong Jang, Dongho Kim Aromaticity tuning in octaphyrins provides a powerful platform for controlling redox behavior, spin states, and stimulus-induced structural reorganization in fully π-conjugated macrocycles. In contrast, asymmetric multicyclic systems incorporating fused, bridged...

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03059A, Edge Article Ross E. MacKenzie, Benjamin Réant, Iain Cameron, Harry Silver, George F. S. Whitehead, Eric J L McInnes, Conrad Alexander Phillip Goodwin Molecular rare-earth (RE) complexes in the divalent oxidation state have been used as potent one-electron reductants, yielding bonding motifs not accessible elsewhere in the periodic table. A deeper understanding of...

This study unveils aggregation-induced singlet fission (SF) in water-dispersed organic nanoaggregates. The research focuses on push-pull para-azaquinodimethane (pAQM) derivatives, investigating both asymmetrical and symmetrical molecular structures. These nanoaggregates demonstrate SF, a process where one high-energy exciton splits into two lower-energy excitons upon aggregation. The findings highlight the potential of these pAQM derivatives for applications requiring efficient exciton splitting.

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC02904C, Review Article Meng Zhou, Mengna Zhang, Qian Zhang, Xinming Ma, Hui Fang, Huanhuan Dong, Xiang Chen, Jianchao Sun, Lin Li, Xunzhu Zhou Potassium-ion batteries (PIBs) are regarded as promising candidates for large-scale grid energy storage owing to the abundant reserves of potassium resources. Iron hexacyanoferrate (FeHCF), a type of Prussian blue analogue,...