Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC03993F, Edge Article Dongmei Xi, Wencai Jiang, Mengyue Li, Jialu Guo, Pengxiang Wang, Fangqian Yin, Xiaopeng Fan, Ke-Rang Wang, Wen Sun, Xiaojun Peng Glycosylated NBS-Lac forms H-aggregates to enhance charge transfer and ISC, boosting O2˙− production. This hypoxia-active photosensitizer achieves potent antibiofilm activity and accelerates diabetic wound healing with excellent biosafety.