Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC01387B, Edge Article Peilin Tian, Viktor Saraiva Câmara, Margarita Valentine, Andrew P Tinkler, Agamemnon E. Crumpton, Edward A. Anderson Asymmetric inverse electron-demand Diels-Alder (IEDDA) cycloadditions of thiophene S,S-dioxides (TDOs) remain largely unexplored. Here we report the development of highly enantioselective titanium-catalyzed IEDDA reactions between TDOs and indenes which enables...