Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC03721F, Edge Article Jun-Jie Chen, Yi-Hui Tang, Pei-Yuan Bai, Huan-Ming Huang The development of complex fluorinated bicyclic scaffolds as benzene bioisosteres has emerged as a powerful strategy in drug discovery, yet efficient and general synthetic routes to these structures remain limited....