Chem. Sci., 2026, Advance Article DOI: 10.1039/D6SC02205G, Edge Article Zhanyu He, Celine Janssen, Joana-Lysiane Schäfer, Agnes Mühlenweg, Simone Kosol, Rene Jarling, Andi Mainz, Bettina G. Keller, Guiyang Yao, Enno Klussmann, Roderich D. Süssmuth First total synthesis of cortinarins A–C, cryptic cyclic peptides exhibiting non-classical atropisomerism. They mimic vasopressin-induced aquaporin-2 membrane localization through a distinct mode of action, offering leads for diabetes insipidus.