Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC02631A, Edge Article haomeng hu, Renjie Zhu, Ning Zhu, Chengyun Zhang, Tianfeng Shang, Chongyang Li, Jingjing Guo, Xu-Dong Wang, Hongliang Duan Cyclic peptides are promising scaffolds for targeting protein surfaces due to their unique structural and functional advantages. However, the limited availability of cyclic peptide-protein complex structures severely restricts the design...