Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC04911G, Edge Article Yunlong Zhao, Kaidi Zhu, Feng Zhao, Yanxia Zhang, Chuanfa Ni, Jinbo Hu The difluoromethylene (-CF2-) motif is highly valuable in pharmaceuticals, agrochemicals, and materials science due to its unique physicochemical properties. Herein, we present a broadly applicable strategy for the modular synthesis...