Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D6SC01141A, Edge Article Xin-Yu Luo, Jie Liu, Xuemei Zhou, Yan-Mei Lei, Lu-Xi Wang, Depeng Jiang, Ying Zhuo Chemoresistance, a primary contributor to approximately 90% of cancer-related deaths, stems from the tumor cells’ ability to endure chemotherapy-induced DNA methylation damage via aberrant upregulation of DNA repair enzymes, such...