A General Route to β,β-carbocyclic Sidechains in Peptides: An Aqueous Metallaphotoredox Approach Driven by Green Light

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D5SC08845C, Edge Article Samuel Gary, Pei-Hsuan Chen, Nin Mai, Steven Bloom Amino acids with β,β-carbocyclic sidechains are valuable replacements for endogenous Val, Leu, and Ile, with therapeutic benefits. When placed into ordinary peptides, these annulated variants improve metabolic stability, cell permeability,...