A Snapshot Of Flavin-Conjugate... Note

A Snapshot Of Flavin-Conjugated Pt Anticancer Agents: Pt(IV)-To-Pt(II) Reduction Revealed By X-Ray Fluorescence Imaging And XANES

Chem. Commun., 2025, Accepted Manuscript DOI: 10.1039/D5CC04792G, Communication Esteban Zingales, Juan Sanchez-Camacho, Carlos Sanchez-Cano, Jessica M Walker, Luca Salassa Synchrotron-based X-ray spectromicroscopy reveals enhanced cellular uptake and remarkably fast, efficient photoactivation of Pt(IV) prodrugs bearing flavin groups. These features correlate with superior anticancer activity compared to non-conjugated analogues, highlighting...