Chem. Commun., 2025, Advance Article DOI: 10.1039/D5CC03915K, Communication Qizhi Liang, Yuying Pan, Qianxi Zhou, Jiahua Yang, Hai Shi, Chenbo Ji, Genxi Li An electrochemical biosensor based on nucleic acid isothermal amplification enhanced metal–organic framework self-assembly. This biosensor has the potential to be used for molecular typing and drug guidance of breast cancer.