Anomeric oxyacetamide assisted site-selective C-2 arylation and its application in O/S glycosylation of 2,3 eno-pyranoside

Chem. Commun., 2024, Advance Article DOI: 10.1039/D4CC04301D, Communication Irshad Ahmad Zargar, Bisma Rasool, S. K. Bappa, Debaraj Mukherjee We report a site-selective Pd(II)-catalyzed C–H activation of 2,3-enopyranosides using an oxyacetamide directing group, synthesizing a variety of C-2 aryl sugars. This methodology was further applied to O/S glycosylation, enabling the regio- and stereoselective formation of 1,2-disubstituted sugars.