Chem. Commun., 2026, Accepted Manuscript DOI: 10.1039/D6CC02191C, Communication Jacob Eicholtz, Ryanna Tuttle, Dylan Hohlfelder, Satya Arya, Andrew Franklin Manazer, Xiaohong Tan Rapid detection of emerging coronaviruses is critical for preparedness. The S2A2C1 aptamer broadly recognizes betacoronavirus S2 domains but not influenza proteins. A sandwich aptamer assay achieved ~0.33 pM detection limits...