Chem. Commun., 2025, Accepted Manuscript DOI: 10.1039/D5CC05132K, Communication Xiang Liu, Wen-Rong Wu, Shaohong Ma, Juan Chen, Yuan-Jie Meng, Zi-Feng Yang, Shang-Shi Zhang, Pengju Feng A base-promoted [3+2] cycloaddition between N-aminoisoquinolinium/N-aminoquinolinium derivatives and cyclic iodonium ylides/2,2-difluorovinyl tosylate has been developed, enabling efficient access to polycyclic pyrazolo[5,1-a]isoquinolines and 1-fluoropyrazolo[5,1-a]isoquinoline frameworks with good yields and broad substrate...