Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC06589E, Edge Article Rochelle Ahmed, Danoo Vitsupakorn, Kieran D Hartwell, Karma Albalawi, Pierre Rizkallah, Peter Watson, D. Dafydd Jones Here, we have linked one of the most common protein-protein interaction events, homodimerisation, to an essential trace metal, copper, through engineering green fluorescent protein. Mutation of H148 to cysteine promotes...