Colorectal cancer rates are on the rise across all age groups up to 69. A recent study published in NEJM Evidence highlights this concerning trend, with overall incidence rates increasing for the first time in over two decades. The age-adjusted incidence rate saw a rise from 36.7 per 100,000 in 2022 to 38.3 in 2023. While increased screenings among younger adults are catching cancers earlier, this doesn't explain the rise in older demographics. Researchers suggest unknown risk factors may be offsetting screening benefits for those aged 65 to 69. The study's lead author believes that whatever causes colorectal cancer in younger individuals may now be affecting older populations as well. Colorectal cancer is now the leading cause of cancer deaths for those under 50. Theories for the root cause are diverse, with a study suggesting faster biological aging might be a contributing factor. Future research will explore environmental chemical exposures as a potential culprit. Scientists plan to test these chemicals on organoids to understand their impact on colon development.