Controlled Condensation Reaction of an Immobilized Bis(hydroxymethyl)arene and Mobile Phenols in Metal-Organic Frameworks
Chem. Commun., 2025, Accepted Manuscript DOI: 10.1039/D5CC04305K, Communication
Mariko Tsutsumi, Hiroki Amaya, Keitaro Matsuoka, Kazuki Sada We report a Sc(OTf)₃-catalyzed Friedel–Crafts alkylation between immobilized bis(hydroxymethyl)arenes in MOFs and mobile electron-rich arenes. Reactivity is controlled by guest concentration: high concentrations yield mono-substitution (post-synthetic modification), while low concentrations...
