Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D4SC06628F, Edge Article Atreyee Mishra, Dominic J. Black, Thomas S Bradford, Karrera Djoko, Benjamin J Hofmann, Jamie J Hunter, Rianne M. Lord, Robert Pal, Harvey James Smart, Tameryn Stringer, James William Walton Copper complexes have great potential to overcome the disadvantages of platinum-based anticancer agents, owing to their lower systemic toxicity. Copper pyrithione showed early promise as an anticancer candidate, but further...