Cases of cyclosporiasis, a food-borne parasitic infection, have been reported in at least 41 states, with declared outbreaks in five specific states. This situation is making 2026 the worst year on U.S. record for this illness. The CDC reported 4,173 confirmed cases between May 1 and July 20, already surpassing the total for all of 2025. Investigations are currently focusing on contaminated iceberg lettuce as the likely source of the outbreak. Michigan shows the highest number of lab-confirmed domestic cases, estimated between 900 and 2,100, resulting in an infection rate of nearly 15 per 100,000 people. Ohio, Indiana, Kentucky, and West Virginia are also experiencing outbreaks. The actual number of cases is likely higher than reported, as the CDC is aware of thousands more unconfirmed cases and many sick individuals are not tested. While some cases occur annually, the current concentration and growth of cases are particularly concerning to health agencies. There is a watch on whether case numbers will continue to rise in the coming weeks due to the reporting lag. Ultimately, case totals are expected to worsen before any improvement.