Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC05053G, Edge Article Chunying Chen, Qijie Mo, Fuzhen Li, Haili Song, Qingsheng Gao, Li Zhang Single-atom layer clusters (SLCs) have demonstrated high catalytic potentials owing to the fully exposed metal sites, alloying effects and unique electronic structures. However, it is challenging for the precise fabrication...