Design, synthesis and biological activity of potential retrometabolic polymyxins via thiol–ene chemistry

Chem. Commun., 2025, Advance Article DOI: 10.1039/D5CC03871E, Communication Catherine Smith, Andrew Siow, Renata Kowalczyk, Scott A. Ferguson, Matigan J. B. Smith, Gregory M. Cook, Veronika Sander, Alan J. Davidson, Margaret A. Brimble, Paul W. R. Harris Despite their nephrotoxicity, polymyxins remain in clinical use as last-resort antibiotics, underscoring the urgent need for alternatives amid rising antimicrobial resistance.