Enantioselective Pd&Cu-Catalyzed Coupling of Imine Esters with gem-Difluorinated Cyclopropanes

Chem. Commun., 2026, Accepted Manuscript DOI: 10.1039/D6CC00880A, Communication Deyue Ren, Jie Zhao, Jin-Tao Xia, He Zhang, Yingchun Qiu, Ziqi Yu, Jinping Hu, Tianhao Li, Fang Xie This work details a Pd/Cu-cocatalyzed coupling of imine esters with gem-difluorinated cyclopropanes to access enantiomerically enriched α-quaternary 2-fluoroallylic 2H-pyrroles. The bimetallic catalyst system demonstrates a broad substrate scope and high...