Chem. Commun., 2026, Accepted Manuscript DOI: 10.1039/D6CC01258B, Feature Article Camilla Nielsen, Katja Grier, Laura Rosenkrands, Andreas Hemmingsen, Charlotte Jansen, Nicolai Lindegaard, Kirstine Nørregaard, Oliver Krigslund, Niels Behrendt, Lars Henning Engelholm, Katrine Qvortrup Antibody-drug conjugates (ADCs) consisting of monoclonal antibodies covalently conjugated to cytotoxic agents via engineered chemical linkers enable targeted delivery of cytotoxic payloads directly to tumor cells, minimizing off-target effects. It...