Chem. Commun., 2025, Accepted Manuscript DOI: 10.1039/D5CC05182G, Communication Xiangdan Meng, Sirong Sun, Xueji Zhang, Haifeng Dong In this work, we construct a glutathione (GSH)-activated DNA nanodevice conjugated to a porphyrin-based metal–organic framework (PCN-224), creating an integrated theranostic platform for modulating hypoxia, enabling miRNA-210-specific imaging and enhancing...