Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC05442G, Edge Article Hera Thao Nguyen, Nicolau Sbaraini, Joe Bracegirdle, Luke Smithers, Stephen A. Moggach, Daniel Vuong, Ernest Lacey, Peter S. Solomon, Joel Haywood, Andrew M Piggott, Yit-Heng Chooi Depsides are polyphenolic natural products commonly found in lichens, but also produced by some free-living fungi. Here, we report the discovery and functional characterisation of an in planta-upregulated biosynthetic gene...