Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC04715C, Edge Article Florian Wagner, Gernot Neun, Thomas Tampone, Zhen Lei, Frederic Buono, Christopher A. Hone, C. Oliver Kappe In this work we describe the development of a chemistry-based encoding approach utilizing nucleophilicity to perform Bayesian optimization campaigns. A fully automated slug continuous flow platform leveraging a liquid handler...