Lewis acid-catalyzed (3+2) annulation of bicyclobutanes with ynamides: Access to 2-amino bicyclo[2.1.1]hexenes

Chem. Sci., 2024, Accepted Manuscript DOI: 10.1039/D4SC03893B, Edge Article Deeptanu Sarkar, Shiksha Deswal, Rohan Chandra Das, Akkattu T. Biju Strain-release driven annulations with bicyclo[1.1.0]butanes (BCBs) have become an attractive area of research for the synthesis of bioisosteric bicyclohexane derivatives, which play a vital role in drug discovery. Interestingly, the...