Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC04781A, Perspective Dylan T. Holden, Brison A. Shira, Myles Edwards, Nicolás M Morato, R. Graham Cooks Over the past decade the use of electrospray ionization mass spectrometry (ESI-MS) has been extended from the domain of chemical analysis to that of chemical synthesis. This development was spurred...