Photochemical Cyclization of α-Amino Esters to Access 3-Azetidinones

Chem. Sci., 2026, Accepted Manuscript DOI: 10.1039/D5SC09994C, Edge Article Meemie U Hwang, Achyut R Gogoi, Matthew Scurria, Osvaldo Gutierrez, Karl A Scheidt A light-driven cyclization of readily available a-amino esters to 3-azetidinones has been developed. This method leverages chromophore activation with the acyl imidazole to generate the triplet diradical species under mild...