Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC03816B, Edge Article Hao Lu, Eduard Wiedenbeck, Moritz Macht, Daizong Qi, Ali Dhinojwala, Han Zuilhof, Dirk Zahn, Helmut Cölfen, Mischa Bonn We compare the pH-triggered nucleation of the pharmaceutical diclofenac in bulk solution and at the air-water interface, using a combination of cryo-transmission electron microscopy, surface-specific spectroscopy and microscopy, and molecular...