Chem. Sci., 2025, Advance Article DOI: 10.1039/D5SC05777A, Edge Article Huijuan Chen, Yuan Xue, Nan Yao, Rong Cheng, Jia Liu, Jiawen Bao, Zan Hua Bioinspired nucleobase interactions enable us to elegantly fabricate precise polymer nanostructures with controlled sizes, tunable surface properties, and spatially defined functionalities by overcoming the strong steric hindrance of polymers.