Chem. Commun., 2026, Accepted Manuscript DOI: 10.1039/D6CC02966C, Communication Andrew Michael Reynolds, Hari Prasad Timilsina, Pavel Anzenbacher, Xiaohong Tan Fluorogenic fusion aptamer sensor design is complicated by troubleshooting with increased labor and cost. Secondary structure prediction software can help reduce the number of designs to screen experimentally. We propose...