Science Magazine | AAAS: Science Translational Medicine

Science Magazine | AAAS: Science Translational Medicine
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Science Translational Medicine (STM) is a scientific journal published by the American Association for the Advancement of Science. The journal focuses on publishing original research that bridges basic science discoveries with clinical applications to enhance human health. It covers a wide range of biomedical fields, including drug discovery, vaccine development, medical devices, and diagnostics. STM aims to facilitate the translation of scientific breakthroughs into practical solutions for patients. The journal's target audience includes researchers, clinicians, policymakers, and others interested in the latest advancements in translational medicine. By disseminating cutting-edge research and fostering collaboration, STM plays a vital role in advancing human health and well-being.

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AAAS: Science Translational Medicine: Table of Contents science.org

RSS Hunter • Aug 19, 2024

Thread Of Notes

Deep learning–enabled discovery of antibiotics effective against Neisseria gonorrhoeae | Science Translational Medicine

The development, validation, and deployment of a deep learning model to identify antibiotic hit compounds for N. gonorrhoeae is described.

https://www.science.org/doi/10.1126/scitranslmed.ads4699 science.org

RSS Hunter • Yesterday

Plasma proteomics improves thrombosis prediction in patients with cancer and identifies targetable IL-17–driven endothelial activation | Science Translational Medicine

Plasma proteomics improves thrombosis prediction in cancer and uncovers a targetable CD200R1/IL-17–driven endothelial activation pathway in mice.

https://www.science.org/doi/10.1126/scitranslmed.adu7160 science.org

RSS Hunter • Yesterday

The translational potential of drug-induced hypothermia in acute ischemic stroke | Science Translational Medicine

Hypothermia induced by chlorpromazine and promethazine is cerebroprotective in animal models and safe in patients with ischemic stroke.

https://www.science.org/doi/10.1126/scitranslmed.ady7847 science.org

RSS Hunter • Yesterday

Donor bone marrow together with recipient regulatory T cells induces chimerism without irradiation in kidney transplantation | Science Translational Medicine

Donor bone marrow combined with recipient regulatory T cells induces chimerism and immunomodulation without irradiation in kidney transplantation.

https://www.science.org/doi/10.1126/scitranslmed.aee6850 science.org

RSS Hunter • Yesterday

Clinicogenomic analysis of EGFR-mutant lung tumors identifies Rb pathway inactivation as a hallmark of squamous transformation | Science Translational Medicine

Integrated clinical, multiomic, and single-cell analyses reveal Rb inactivation as a driver of squamous transformation in EGFR-mutant lung cancer.

https://www.science.org/doi/10.1126/scitranslmed.aea4881 science.org

RSS Hunter • Yesterday

Engineered antibodies bypass bacterial immune evasion to drive complement-mediated protection against lethal infections | Science Translational Medicine

Incorporation of enzyme domains that initiate complement activation on target surfaces improves the utility of pathogen-targeting antibodies.

https://www.science.org/doi/10.1126/scitranslmed.adx4108 science.org

RSS Hunter • Yesterday

Immune microenvironment and noncoding RNA shape early colorectal carcinogenesis in patients with premalignant lesions | Science Translational Medicine

Colorectal polyp risk is associated with adaptive local immune response and noncoding RNA expression.

https://www.science.org/doi/10.1126/scitranslmed.aed2424 science.org

RSS Hunter • Jun 10

IL-27–mediated hematopoietic dysregulation exacerbates disease severity in severe fever with thrombocytopenia syndrome virus infection | Science Translational Medicine

IL-27 potentiates severe fever with thrombocytopenia syndrome by disrupting hematopoiesis and amplifying inflammation.

https://www.science.org/doi/10.1126/scitranslmed.adu7243 science.org

RSS Hunter • Jun 10

A cocktail of human mAbs targeting the henipavirus fusion and receptor binding proteins provides cross-species neutralization | Science Translational Medicine

A cocktail of antibodies binding the fusion and receptor binding proteins of Nipah and Hendra viruses provides protection and resilience to resistance.

https://www.science.org/doi/10.1126/scitranslmed.adw8573 science.org

RSS Hunter • Jun 10

The pyrrolidinamide antimalarial drug MMV367 rapidly clears blood-stage Plasmodium falciparum in healthy adults with experimental malaria | Science Translational Medicine

The fast-acting antimalarial drug MMV367 rapidly killed blood-stage parasites in healthy volunteers experimentally infected with Plasmodium falciparum.

https://www.science.org/doi/10.1126/scitranslmed.aec1863 science.org

RSS Hunter • Jun 10

SARS-CoV-2 variant booster vaccination and infection alter the breadth of the memory B cell repertoire | Science Translational Medicine

SARS-CoV-2 vaccination and infection differentially shift the memory B cell pool.

https://www.science.org/doi/10.1126/scitranslmed.aeb9847 science.org

RSS Hunter • Jun 10

Clinical validation of an HPV whole-genome sequencing assay for MRD detection in patients with HPV+ head and neck cancer treated with surgery | Science Translational Medicine

An ultrasensitive blood test accurately detects residual disease after surgery and predicts recurrence and survival in HPV+ head and neck cancer.

https://www.science.org/doi/10.1126/scitranslmed.aec1724 science.org

RSS Hunter • Jun 10

HIV-1 infection converts CD4+ T cells to HLA class II–restricted CD8+ T cells | Science Translational Medicine

HIV-1–driven CD4-to-CD8 T cell conversion results in a distinct cellular reservoir of viral persistence.

https://www.science.org/doi/10.1126/scitranslmed.aec4912 science.org

RSS Hunter • Jun 3

Hiding in plain sight | Science Translational Medicine

HIV-1–infected CD4+ T cells undergo lineage marker changes to become induced CD8+ T cells that harbor latent HIV-1 (Cai et al., this issue).

https://www.science.org/doi/10.1126/scitranslmed.aeh0704 science.org

RSS Hunter • Jun 3

Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction | Science Translational Medicine

Cryptic RNA splicing in synaptic and membrane excitability genes caused by TDP-43 loss impairs neuronal function.

https://www.science.org/doi/10.1126/scitranslmed.aeb8517 science.org

RSS Hunter • Jun 3

Neutralizing antibodies elicited in nonhuman primates by an enterovirus D68 virus-like particle vaccine target receptor binding sites | Science Translational Medicine

An enterovirus D68 virus-like particle vaccine elicits potent neutralizing antibodies targeting receptor binding sites in nonhuman primates.

https://www.science.org/doi/10.1126/scitranslmed.aec5446 science.org

RSS Hunter • Jun 3

Claudin-1 targeting suppresses tumor growth, invasion, and metastasis in patient-derived cholangiocarcinoma models | Science Translational Medicine

Exposed claudin-1 is a mediator and therapeutic target for cholangiocarcinoma.

https://www.science.org/doi/10.1126/scitranslmed.adp2595 science.org

RSS Hunter • Jun 3

Toll-like receptor 5 protects against murine lung fibrosis through reduced dysbiosis, and TLR5 deficiency is associated with human IPF | Science Translational Medicine

TLR5 deficiency is associated with idiopathic pulmonary fibrosis, and TLR5 activation reduces lung dysbiosis and protects against fibrosis in mice.

https://www.science.org/doi/10.1126/scitranslmed.adw1028 science.org

RSS Hunter • Jun 3

Treatment of Shiga toxin–producing E. coli infection by CRISPR-Cas–targeted cleavage of the Shiga toxin gene in animal models | Science Translational Medicine

A phage-derived particle killed more than 90% of STEC O157 strains via CRISPR-Cas targeting stx, reducing bacterial loads and symptoms in animals.

https://www.science.org/doi/10.1126/scitranslmed.adw8114 science.org

RSS Hunter • May 27

The PET tracer [11C]MODAG-005 targets alpha-synuclein aggregates in the brain | Science Translational Medicine

[11C]MODAG-005 showed high-affinity binding to α-synuclein aggregates and was validated in brain tissues, preclinical models, and first-in-human imaging.

https://www.science.org/doi/10.1126/scitranslmed.aec0813 science.org

RSS Hunter • May 27

Coordinated regulation using small-molecule drugs enables controlled therapeutic genome editing and enhanced genomic precision in situ | Science Translational Medicine

Coordinated delivery of small-molecule drugs allows precise control over therapeutic genome editing directly in situ in mouse models.

https://www.science.org/doi/10.1126/scitranslmed.adx7857 science.org

RSS Hunter • May 27

Genomic instability drives POSTN+ myofibroblasts via STING-WNT axis to promote immunosuppression and PARPi resistance in ovarian cancer | Science Translational Medicine

Epigenetic reprogramming of POSTN+ myCAFs converts genome instability–induced immune activation into suppression, promoting PARP inhibitor resistance.

https://www.science.org/doi/10.1126/scitranslmed.ady2719 science.org

RSS Hunter • May 27

Efficacy and safety of durcabtagene autoleucel in a phase 1 trial for patients with relapsed/refractory multiple myeloma | Science Translational Medicine

Durcabtagene autoleucel, a rapidly manufactured BCMA-directed CAR T cell therapy, was safe and efficacious in relapsed/refractory multiple myeloma.

https://www.science.org/doi/10.1126/scitranslmed.adx1799 science.org

RSS Hunter • May 27

CCR5 and CD74 are potential therapeutic targets for necroinflammation in preclinical cholesterol crystal embolism | Science Translational Medicine

Inhibition of CCR5 and CD74 offers a new strategy to curb necroinflammation and thrombosis.

https://www.science.org/doi/10.1126/scitranslmed.adv8372 science.org

RSS Hunter • May 27

Reprogrammed apoptotic platelets drive rapid hemostasis through phosphatidylserine and prostaglandin E2 signaling in preclinical models | Science Translational Medicine

Reprogrammed apoptotic platelets stop complex bleeding through surface phosphatidylserine and PTGES/PGE2 signaling.

https://www.science.org/doi/10.1126/scitranslmed.aea0189 science.org

RSS Hunter • May 21

Real-time in vivo analysis of murine β cells reveals autophagic flux defects before onset of autoimmune diabetes | Science Translational Medicine

Dynamic in vivo 4D analysis of β cell autophagic flux in mice reveals early impairment in the type 1 interferon response before the onset of autoimmune diabetes.

https://www.science.org/doi/10.1126/scitranslmed.adj4902 science.org

RSS Hunter • May 20

Erratum for the Research Article “In vivo generation of CAR myeloid cells through erythrocyte-mediated mRNA delivery for cancer immunotherapy” | Science Translational Medicine

In the published version of the Research Article “In vivo generation of CAR myeloid cells through erythrocyte-mediated mRNA delivery for cancer immunotherapy” by X. Nie et al., three images in Fig. 1I—those depicting E-LNP-mEry–, Cre-LNP–, and Cre-LNP-mEry–mediated gene expression in the livers of Cre reporter mice—were inadvertently placed in the wrong order. The figure has been corrected, and the data and conclusions are not affected.

https://www.science.org/doi/10.1126/scitranslmed.aei4459 science.org

RSS Hunter • May 20

Sotatercept reduces bone morphogenetic protein signaling in patients with pulmonary arterial hypertension | Science Translational Medicine

A BMP target engagement biomarker panel, developed through the StratosPHere 1 study, demonstrates that sotatercept reduces BMP signaling in PAH.

https://www.science.org/doi/10.1126/scitranslmed.ads5175 science.org

RSS Hunter • May 20

Treating the immune system to repair the brain | Science Translational Medicine

Targeting the systemic immune system in Alzheimer’s disease restores immune-mediated neuroprotection that dampens brain inflammation.

https://www.science.org/doi/10.1126/scitranslmed.aeb1677 science.org

RSS Hunter • May 20

A long-term image-derived AI-based risk model for primary prevention of breast cancer in individuals at high risk | Science Translational Medicine

A long-term risk model for use in primary prevention was designed to identify individuals at high risk of developing breast cancer in the coming 10 years.

https://www.science.org/doi/10.1126/scitranslmed.ady7414 science.org

RSS Hunter • May 20

Urinary fluorogenic reporters for noninvasive detection and staging of kidney fibrosis | Science Translational Medicine

Fibrogenesis sensing reporters provide a noninvasive approach for identification of kidney fibrosis with point-of-care urinalysis.

https://www.science.org/doi/10.1126/scitranslmed.adz6929 science.org

RSS Hunter • May 20

A mitochondrial ROS–dependent antiviral response promotes β cell resilience and is diminished in donors with type 1 diabetes | Science Translational Medicine

IFN-α stimulates mitochondrial ROS production in a subset of healthy human β cells, potentially indicating a more efficient antiviral response.

https://www.science.org/doi/10.1126/scitranslmed.adx7770 science.org

RSS Hunter • May 20

Transcranial ultrasound stimulation of motor networks in Parkinson’s disease informed by local field potential dynamics | Science Translational Medicine

TUS can alter subthalamic activity in a target-specific, frequency band–specific, and brain state–specific manner in Parkinson’s disease.

https://www.science.org/doi/10.1126/scitranslmed.ady1883 science.org

RSS Hunter • May 20

Prime editing of a pathogenic Scn1a allele ameliorates seizure phenotypes in a GEFS+ mouse model | Science Translational Medicine

Prime editing corrects a pathogenic human SCN1A mutation in mice, reducing seizure frequencies and improving survival in this GEFS+ model.

https://www.science.org/doi/10.1126/scitranslmed.adz2557 science.org

RSS Hunter • May 13

Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts | Science Translational Medicine

NKG2A checkpoint inhibition promotes lung fibrosis resolution.

https://www.science.org/doi/10.1126/scitranslmed.adq5442 science.org

RSS Hunter • May 13

Sensory nerves protect against preclinical tendinopathic changes through FGF1 signaling | Science Translational Medicine

Somatosensory neurons prevent tendon degeneration by FGF1-mediated mesenchymal and macrophage regulation.

https://www.science.org/doi/10.1126/scitranslmed.aec1380 science.org

RSS Hunter • May 13

In vivo adenine base editing ameliorates Dravet syndrome phenotypes in a mouse model | Science Translational Medicine

Through direct correction of a mutation causing Dravet syndrome, adenine base editing alleviates epileptic and premature mortality phenotypes in mice.

https://www.science.org/doi/10.1126/scitranslmed.adx5999 science.org

RSS Hunter • May 13

A platform for near real-time and multiplexed monitoring of cerebrospinal fluid biomarkers and flow in neurocritical care | Science Translational Medicine

NeuroSense enables near real-time, multimodal monitoring of external ventricular drains in neurocritical care.

https://www.science.org/doi/10.1126/scitranslmed.aeb1381 science.org

RSS Hunter • May 13

RNA-LNP–mediated in vivo prime editing corrects disease phenotypes in a mouse model of citrullinemia type I | Science Translational Medicine

Prime editing via RNA-LNP corrects multiple pathogenic ASS1 mutations and restores ureagenesis and survival in a mouse model of citrullinemia type I.

https://www.science.org/doi/10.1126/scitranslmed.aec7274 science.org

RSS Hunter • May 13

uPAR is highly expressed in recurrent glioblastoma and represents a candidate CAR T cell target | Science Translational Medicine

The urokinase receptor uPAR is highly expressed in recurrent glioblastoma and is targetable using anti-uPAR chimeric antigen receptor T cells.

https://www.science.org/doi/10.1126/scitranslmed.aea8381 science.org

RSS Hunter • May 13

VRC01 with antiretroviral initiation in infants is well tolerated, and higher concentrations associate with greater HIV-1 DNA declines | Science Translational Medicine

VRC01 in infants initiating antiretrovirals was well tolerated and associated with lower HIV-1 DNA when high VRC01 concentrations were sustained.

https://www.science.org/doi/10.1126/scitranslmed.adr4509 science.org

RSS Hunter • May 6

Extracellular traps from myeloid cells as therapeutic targets in traumatic heterotopic ossification | Science Translational Medicine

Extracellular traps from myeloid cells are present at lesion sites of traumatic heterotopic ossification and contribute to ectopic ossification.

https://www.science.org/doi/10.1126/scitranslmed.ady4761 science.org

RSS Hunter • May 6

Polymeric rapamycin nanoparticles encapsulating ponatinib cause regression of venous malformations in mice | Science Translational Medicine

A single dose of polymeric rapamycin nanoparticles encapsulating ponatinib drove regression of venous malformations in a preclinical model.

https://www.science.org/doi/10.1126/scitranslmed.aeb7597 science.org

RSS Hunter • May 6

CD39+CD49a+CD103+ cytotoxic tissue-resident natural killer cells infiltrate and control solid epithelial tumor growth in mice | Science Translational Medicine

CD39+CD49a+CD103+ natural killer cells, elicited by epithelial tumor cell exposure, can control solid tumors in mice.

https://www.science.org/doi/10.1126/scitranslmed.adw5567 science.org

RSS Hunter • May 6

Targeting RBPMS selectively eliminates FOXO1-mediated stem cell signatures in mouse models of acute myeloid leukemia | Science Translational Medicine

RBPMS-mediated posttranslational modification plays a crucial role in leukemogenesis by reprogramming FOXO1-mediated glucose metabolism.

https://www.science.org/doi/10.1126/scitranslmed.adv8951 science.org

RSS Hunter • May 6

Erratum for the Research Article “Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice” | Science Translational Medicine

In the Research Article “Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice” by J. Shao et al., an incorrect fluorescence image was inadvertently included in fig. S6 during figure assembly. To address this issue, the authors repeated the corresponding experiment and obtained results consistent with the original findings. The figure has now been corrected with the appropriate representative image. This correction does not affect the conclusions of the paper.

https://www.science.org/doi/10.1126/scitranslmed.aeh9233 science.org

RSS Hunter • May 6

Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis | Science Translational Medicine

Lactate transport inhibitors reprogram fibroblast metabolism to prevent myofibroblast differentiation and reduce pulmonary fibrosis.

https://www.science.org/doi/10.1126/scitranslmed.ads2673 science.org

RSS Hunter • May 6

The internal limiting basement membrane inhibits functional engraftment of transplanted human retinal ganglion cells in vivo | Science Translational Medicine

Disrupting the ILM in vivo permits retinal integration of transplanted RGCs, enabling connectivity to light-sensing retinal circuits.

https://www.science.org/doi/10.1126/scitranslmed.adr1062 science.org

RSS Hunter • Apr 29

Clinical cure of chronic hepatitis B is associated with priming and perpetuation of hepatic CD4+ T cell responses | Science Translational Medicine

Samples from patients with chronic hepatitis B and a mouse model revealed a central role for CD4+ T cells in hepatitis B virus clearance.

https://www.science.org/doi/10.1126/scitranslmed.adx1523 science.org

RSS Hunter • Apr 29

Dipeptidyl aminopeptidase–like protein 6 regulates the INa-Ito balance influencing cardiac electrophysiology and arrhythmogenesis | Science Translational Medicine

DPP6 regulates the cardiac INa-Ito balance, which is aberrantly influenced by clinically relevant DPP6 gene variants.

https://www.science.org/doi/10.1126/scitranslmed.adn3180 science.org

RSS Hunter • Apr 29