Chem. Commun., 2026, Accepted Manuscript DOI: 10.1039/D6CC01655C, Feature Article Sumit Garai, Sureshkumar Devarajulu Fluorinated alkyl groups play a crucial role in medicinal chemistry by modulating molecular conformation, metabolic stability, lipophilicity, and biological activity. Among these, the trifluoroethyl (-CH2CF3) group has emerged as a...