Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC02398J, Edge Article Takumi Ueda, Tomoki Tsuchida, Masanori Kurita, Takuya Mizumura, Shunsuke Imai, Yutaro Shiraishi, Yutaka Kofuku, Shukei Miyagawa, Kaori Fukuzawa, Koh Takeuchi, Ichio Shimada Residence time, which refers to the average duration a drug remains bound to its receptor, is a crucial parameter in determining its pharmacological effects. However, the mechanisms governing the residence...