The effect of peptide size on target affinity in mRNA display-derived macrocyclic peptides

Chem. Commun., 2026, Advance Article DOI: 10.1039/D5CC06167A, Communication Xuefei Jing, Jen Suh, Joshua Maxwell, Karishma Patel, Alexander Norman, Xavier J. Reid, Chandrika Deshpande, Jason K. K. Low, Richard J. Payne, Toby Passioura, Joel P. Mackay This study demonstrates how peptide size influences the likelihood of identifying highly potent binders in mRNA display screens, providing practical guidance for balancing peptide size and affinity during binder discovery.