Visible-Light-Induced Perfluoroalkylation Cyclization to Access Perfluoroalkylated Benzazepines and Benzoxepines by EDA Complexes

Chem. Commun., 2026, Accepted Manuscript DOI: 10.1039/D5CC07148H, Communication Anxu Pan, Wanqing Zhao, Cuifu Jiang, Man Zhang, Nengneng Zhou A visible-light-mediated perfluoroalkylation/cyclization of N-allyl-N-(2-(3,3-bis(methylthio)acryloyl)aryl)-4-methylbenzenesulfonamides and 1-(2-(allyloxy)aryl)-3,3-bis(methylthio)prop-2-en-1-ones for the synthesis of perfluoroalkylated benzazepines and benzoxepines is developed. This protocol features photocatalystfree, simple operation, and good regioselectivity, providing a novel environmentally...